Metal Ion Effects on the cis/trans Isomerization Equilibrium of Proline in Short-Chain Peptides: A Solution NMR Study

Thermodynamic origin of cis/trans isomer

Thermodynamic origin of cis/trans isomers of a proline-containing β-turn model dipeptide in aqueous solution: A combined variable temperature 1H-NMR, two-dimensional 1H,1H gradient enhanced nuclear overhauser effect spectroscopy (NOESY), one-dimensional steady-state intermolecular 13C,1H NOE, and molecular dynamics study

✍ Anastasios Troganis; Ioannis P. Gerothanassis; Zafiria Athanassiou; Thomas Mavro 📂 Article 📅 2000 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 178 KB

The cis/trans conformational equilibrium of the two Ac-Pro isomers of the beta-turn model dipeptide [13C]-Ac-L-Pro-D-Ala-NHMe, 98% 13C enriched at the acetyl carbonyl atom, was investigated by the use of variable temperature gradient enhanced 1H-nmr, two-dimensional (2D) 1H,1H nuclear Overhauser eff