The influence of hepatic artery ligation and of vasopressin on liver tumour blood flow in rats

✍ Scribed by Peter Naredi; Per Lindér; Stig B. Holmberg; Rigmor Söderberg; Göran Carlsson; Bengt Gustavsson; Lars Jacobsson; Dr. Larsolof Hafström

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 585 KB
• Volume: 50
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930500203

✦ Synopsis

Abstract

The blood flow in an experimental adenocarcinoma in the rat liver was determined with the ^133^Xe‐washout technique before and after hepatic artery ligation (HAL). There was an initial reduction of the washout of 50%. This was further reduced after 1 day by 50%, which was maintained for 7 days. Seven days after HAL or sham procedures the ^133^Xe‐washout was of similar magnitude in the liver tumours, although after the sham procedure the tumours were larger (3.4 g vs. 1.5 g). The estimated tumour blood flow was then approximately 0.04 ml × min^−1^ × g^−1^. The influence on normal liver parenchyma of HAL was a reduction at 30 minutes, which was maintained for 7 days. Postacton®—a synthetic vasopressin—did not influence the ^133^Xe‐washout in normal liver parenchyma in non‐tumour, as well as in tumour‐bearing animals. There was no influence of Postacton® on the ^133^Xe‐washout in the liver tumours. Thirty minutes after HAL Postacton® gave a reduction of blood flow in normal liver parenchyma of tumour‐bearing animals, which is thus only from the portal vein. In tumours Postacton® did not significantly reduce the tumour blood flow immediately after HAL. © 1992 Wiley‐Liss, Inc.