The effect of total body microwave hyperthermia and hepatic artery ligation on liver tumors—an experimental study in rats

✍ Scribed by Goran Carlsson; Larsolof Hafström; Anders Hugander; Per-Ebbe Jönsson; Magnus Bolmsjö; Bertil Persson

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 375 KB
• Volume: 22
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930220110

✦ Synopsis

The effect of general microwave hyperthermia and hepatic artery ligation (HAL) was tested on Wistar rats with a transplanted N-methyl-N-nitrosoguanidine-induced adenocarcinoma in the liver. Total body hyperthermia (41.5"C for 1 hour, three times during 24 hours) was given on the same day as HAL, and 1, 2, and 3 days after. HAL induced a slower tumor growth than untreated controls. No additive effect was registered when total body microwave hyperthermia was added to HAL. When hyperthermia was added 2 days after HAL, there was a transient decrease in tumor volume as in the HAL series. Total body microwave hyperthermia added 3 days after HAL induced a faster tumor growth than after HAL alone. When hyperthermia was added the same day and 1 day after HAL, there was a 50% mortality.