The influence of azone on the transdermal penetration of the dopamine D2 agonist N-0923 in freely moving rats
โ Scribed by P.J. Swart; F.A.M. Toulouse; R.A. De Zeeuw
- Book ID
- 113365908
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 451 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0378-5173
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The pharmacokinetics of the dopamine D2 agonist S( -)-2-(N-propyl-N2-thienylethylamino)-5-hydroxytetralin (1, N-0923) after intravenous, intraperitoneal, and oral administration was studied in freely moving male and female albino Wistar rats. In all cases, the dose was
N-0923, a novel aminotetralin dopamine D2 agonist, was shown to effectively reverse parkinsonian symptoms in nine dopa/agonist-responsive Parkinson's disease patients. The drug was given up to 4.5 hours by continuous intravenous (i.v.) infusion using an i.v. pump. The onset of anti-parkinsonian effe