A pharmacokinetic study of the dopamine 0 2 receptor agonist ( S)-(-)-2-(Npropyl-N(2-thienylethyl)amino)-5-hydroxytetralimHCl (K0923) infused in female cynomolgus monkeys over a 4-h period was carried out at International Research and Development Corporation. The purpose of this study was to estimat
Pharmacokinetics of the dopamine D2 agonist S(-)-2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in freely moving rats
โ Scribed by P. J. Swart; R. A. de Zeeuw
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 503 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0022-3549
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โฆ Synopsis
The pharmacokinetics of the dopamine D2 agonist S( -)-2-(N-propyl-N2-thienylethylamino)-5-hydroxytetralin (1, N-0923) after intravenous, intraperitoneal, and oral administration was studied in freely moving male and female albino Wistar rats. In all cases, the dose was
๐ SIMILAR VOLUMES
The present study was designed to characterize the dopamine D 3 receptor agonist R()-7-hydroxy-N,N-di-n-propyl-2-aminotetralin (R()-7-OH-DPAT)-induced changes in locomotor activity in mice. Although R()-7-OH-DPAT (0 . 01ยฑ10 mg/kg) produced a signiยฎcant decrease in horizontal and vertical motility wi
## Abstract Certain aminotetralins are known to be potent dopamine D~2~ receptor agonists. Nโ0923, [โ]2โ(NโpropylโNโ2โthienylethylamino)โ5โhydroxytetralin HCl, recognizes the high and low affinity states of the D~2~ receptor in membranes from bovine caudate with a K~low~ of 79 nM. The selectivity r
The in vitro autoradiographic binding characteristics as well as in vivo imaging characteristics of a dopamine D2 receptor agonist, (R,S)-2-(N-propyl-N-1ะ-11 Cpropyl)amino-5-hydroxytetralin ( 11 C-5-OH-DPAT), were studied. In 3 H-spiperone assays using rat striata, 5-OH-DPAT exhibited an affinity of