The trapping of circular DNA in agarose
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W.W. Dean; B.M. Dancis; C.A. Thomas Jr.
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Article
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1973
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Elsevier Science
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English
⚖ 697 KB
There are excellent methods available for separating superhelical DNA (covalently closed rings) from a mixture of open circular DNA (rings with one or more single-strand interruptions) and linear DNA (1,2). The separation of open circular DNA from linear DNA presents a more difficult problem. While