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The indole 2-3-quinodimethane strategy for the synthesis of indole alkaloids

โœ Scribed by Magnus, Philip; Gallagher, Timothy; Brown, Peter; Pappalardo, Paul

Book ID
120457974
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
849 KB
Volume
17
Category
Article
ISSN
0001-4842

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โœ Patrick D Bailey; Sean P Hollinshead ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 228 KB

~ A simple three step route to 3-(indol-2-yl)--propenoate derivatives of tryptamine has been developed, involving the base-induced ring-opening of protected tetrahydro-8-carbolines that result from a modified Pictet-Spengler reaction. Several recent syntheses of indole alkaloids have utilised Z-prop