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General Approach for the Synthesis of Sarpagine/Macroline Indole Alkaloids. Enantiospecific Total Synthesis of the Indole Alkaloid Trinervine

✍ Scribed by Liu, Xiaoxiang; Cook, James M.


Book ID
127066454
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
62 KB
Volume
3
Category
Article
ISSN
1523-7060

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Enantiospecific total synthesis of the e
✍ Xiaoxiang Liu; Chunchun Zhang; Xuebin Liao; James M. Cook πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 172 KB

The total synthesis of the enantiomer 3En of macroline 3 was completed (from L-tryptophan methyl ester 6) in an overall yield of 12.3% (11 isolated intermediates). The corresponding macroline equivalent 18 was prepared in 14.3% yield. This work provides, for the first time, an opportunity to synthes