The in vitro synthesized and processed human insulin receptor precursor binds insulin
β Scribed by Shawn Tsuda; Masahiro Kaihara; Xiangjun Zhou; Dean Britos; Richard Arakaki
- Book ID
- 117111260
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 210 KB
- Volume
- 457
- Category
- Article
- ISSN
- 0014-5793
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To determine whether hyperinsulinaemia can cause insulin resistance in man and, if so, whether this occurs at a receptor or post-receptor site, nine normal volunteers were infused with insulin for 6 h at a rate (2 mU X kg-1 X min-1) which resulted in steady-state plasma insulin concentrations of 140
Insulin receptors differing structurally from those in other tissues have been demonstrated in brain from many species. Subtle differences in binding properties have been reported between insulin receptors in brain and other tissues, including differences in affinity of pig brain receptors for human