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The Importance of DT-Diaphorase in Mitomycin C Resistance in Human Colon Cancer Cell Lines

โœ Scribed by Paul A. Lambert; Yuan Kang; Bridget Greaves; Roger R. Perry


Book ID
115635750
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
131 KB
Volume
80
Category
Article
ISSN
0022-4804

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Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone E 0 9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of E