Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase
โ Scribed by Wang, X; Doherty, G P; Leith, M K; Curphey, T J; Begleiter, A
- Book ID
- 110002298
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 150 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-0920
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The bioreductive alkylating agent mitomycin C (mitomycin) has been shown to have greater activity under hypoxic than oxic conditions on murine cell lines such as the EMT-6 fibrosarcoma cell line. Solid tumors are known to contain hypoxic cells and are relatively resistant to ionizing radiation and s
Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone E 0 9 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase may be involved in the metabolic activation of E
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