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The impact of R213 mutation on p53-mediated p21 activity

✍ Scribed by Zhang, Yan; Zhang, Yan-jun; Zhao, Hai-yong; Zhai, Qiao-li; Zhang, Ye; Shen, Yu-fei

Book ID
121721958
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
585 KB
Volume
99
Category
Article
ISSN
0300-9084

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## Abstract In addition to the loss of function, mutant p53 can possess a dominant‐negative effect on wild‐type p53 and may also exert gain‐of‐function activity. It is not clear whether the functional status of __p53__ mutation contributes to differences in outcome in endometrial cancer. We collect