Expression of p53 and p21WAF1/CIP1 Proteins in Gastric and Esophageal Cancers (Comparison with Mutations of the p53 Gene)
β Scribed by Toshikatsu Seta; Fumio Imazeki; Osamu Yokosuka; Hiromitsu Saisho; Takao Suzuki; Yoshio Koide; Kaichi Isono
- Book ID
- 110378939
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 644 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0163-2116
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
RNase H 0 reverse transcriptase (GIBCO-BRL, Gaithersburg, MD). ase chain reaction; SSCP, single-strand conformation polymorphism; mRNA, messenger p21 WAF1/CIP1 messenger RNA (mRNA) was amplified with the follow-RNA; cdk, cyclin dependent kinase.
Data are non-existent regarding coincidental alterations in the expression of p53 and its downstream target genes MDM2 and p21 Waf1/Cip1 in gastric carcinogenesis. An immunohistochemical study was therefore performed to examine the interrelationships of p53, MDM2, and p21 Waf1/Cip1 expression in a s
Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21 WAF1/CIP1 is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21 WAF1/CIP1 expre