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The immunological properties of haptens coupled to thymus-independent carrier molecules. IV. The IgG response to dinitrophenylated Ficoll

✍ Scribed by G. G. B. Klaus; Jennifer M. Phillips; J. H. Humphrey; D. W. Dresser; Anne M. Cross

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
783 KB
Volume
6
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

Dinitrophenylated polysucrose (DNP‐Ficoll) elicits T cell‐independent IgM anti‐DNP antibody formation in mice. This antigen also elicits a heterogeneous IgG1 and IgG2 anti‐DNP response, which is operationally as T‐independent as the IgM response. However, a concomitant graft‐versus‐host reaction markedly enhances the IgG response (allogeneic effect). These results confirm those of others, indicating that a certain proportion of the precursors of IgG‐producing cells can be triggered by some T‐independent antigens. However, our results suggest that even with such antigens optimal triggering of IgG precursors requires T cell help.

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The immunological properties of haptens
The immunological properties of haptens coupled to thymus-independent carrier molecules. I. The characteristics of the immune response to dinitrophenyllysinesubstituted pneumococcal polysaccharide (SIII) and levan
✍ G. G. B. Klaus; J. H. Humphrey 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 891 KB

## Abstract The antibody response to the hapten 2,4dinitrophenyl (DNP)lysine coupled to two thymus‐independent carrier molecules (pneumococcal polysaccharide SIII and levan) has been studied in mice. The characteristics of the anti‐hapten response are essentially similar to the response to the ca