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The humanFCG1gene encoding the high-affinity FcγRI maps to chromosome 1q21

✍ Scribed by Erin Dietzsch; Narin Osman; Ian F. C. McKenzie; Margaret Garson; P. Mark Hogarth

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
524 KB
Volume
38
Category
Article
ISSN
0093-7711

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✦ Synopsis

FcyRI is an interferon inducible high-affinity receptor for IgG which is important in antibody dependent killing, the binding of immune complexes and internalization of antibody-coated particles (Unkless et al. 1988;Ravetch and Kinet 1991). Biochemical characterization of FcyRI indicates that it is related to two other FcyR: the low-affinity FcyRII and FcyRIII as well as the highaffinity receptor for IgE-FceRI. Indeed, these receptors form a subfamily of the Ig superfamily (reviewed in Ravetch and Kinet 1991).

Genetic characterization of these receptors indicates that in man there are at least three genes encoding FcyRI (Ernst et al. 1992), three encoding FcyRII, and two encoding FcyRIII proteins (Qiu et al. 1990). Our previous studies using somatic cell hybrids mapped the human FCG1 locus to chromosome 1 (Osman et al. 1992), but the precise location on this chromosome is unknown. By contrast, the genes encoding the lowaffinity FcyRII and III as well as the high-affinity IgE receptor Fc~RI(z have been mapped to a relatively small segment of chromosome 1

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