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The polymorphicFcγreceptor II gene maps to human chromosome 1q

✍ Scribed by Howard O. Grundy; Gary Peltz; Kevin W. Moore; Mitchell S. Golbus; Laird G. Jackson; Roger V. Lebo

Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
794 KB
Volume
29
Category
Article
ISSN
0093-7711

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✦ Synopsis

Human receptors for IgG (Fc,yR) play important roles in the immune response. Expression of the human FcTRH gene may be relevant in immune complex related disorders such as systemic lupus erythematosus and Sjogren's syndrome. We have used spot blot analysis of dual laser-sorted human chromosomes to localize the Fc3,RII gene to human chromosome 1. Spot blot analysis of sorted derivative chromosomes sublocalized the gene to the chromosome 1 long arm (lq12-+q25.1). This subchromosomal localization involved reassigning a reciprocal chromosome translocation breakpoint. We als0 identified Xmn I and Taq I Fc,yRII polymorphic restriction sites that arose before the races diverged. These common Xmn I and Taq I polymorphisms are predicted to be informative for segregation analysis with human diseases in 85 % of all matings.

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