The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints
✍ Scribed by Thompson, David A; Belinsky, Glenn; Chang, Ted H-T; Jones, D Leanne; Schlegel, Robert; Münger, Karl
- Book ID
- 110061066
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 410 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The carcinogenesis of human papillomaviruses type 16 (HPV‐16) is mainly due to its two oncoproteins, E6 and E7. Their carcinogenic features in term of their relationship with Bcl‐2 family are still unclear. We thus aimed to analyze the expression of Bcl‐2 family members, Bcl‐2, Bax, and
The E6 protein of cancer-associated human papillomavirus type 16 (HPV16) binds to cellular p53 and promotes its degradation through the ubiquitin pathway. In an attempt to identify the regions of E6 that could be targetted for functional inhibition, we generated monoclonal antibodies to the HPV16 E6