The human immunoglobulin x locus. Characterization of the duplicated O regions
β Scribed by Walter Pargent; Alfons Meindl; Rainer Thiebe; Sabine Mitzel; Hans G. Zachau
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 822 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Mapping of the duplicated rabbit immunoglobulin x light chain locus The rabbit has two isotypic forms of the immunoglobulin x light chain, K1 and K2, which probably arose by duplication. In the normal rabbit, only traces of K2 light chains are produced. However, K2 levels are elevated in alloty
During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear