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The host—tumor immune conflict: from immunosuppression to resistance and destruction

✍ Scribed by Salem Chouaib; Carine Asselin-Paturel; Fathia Mami-Chouaib; Anne Caignard; Jean Yves Blay

Book ID
104298699
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
699 KB
Volume
18
Category
Article
ISSN
0167-5699

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✦ Synopsis

A successful immune response against a tumor is dependent on the cytokine repertoire present at the tumor site. Salem Chouaib and colleagues discuss evidence that, to escape the immune system, tumor cells not only produce immunosuppressive cytokines but also employ strategies involving altered susceptibility to tumor necrosis factor and Fas cytotoxic pathways and, in some circumstances, use of the Fas ligand to neutralize effector cells.

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## Abstract Evidence is presented for specific in vitro killing of neoplastic target cells in the presence of non‐sensitized lymphoid cells and heat decomplemented sera from mice bearing the respective neoplasms or whose tumors had been removed. Such an effect was observed with sera from mice beari