Enhancing T lymphocytes from tumor-bearing mice suppress host resistance to a syngeneic tumor
β Scribed by A. J. Treves; C. Carnaud; N. Trainin; M. Feldman; I. R. Cohen
- Book ID
- 102822355
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 655 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Immunologically inactive or βeclipsedβ lymphoid cells from advanced tumorβbearing mice were investigated following their adoptive transfer to irradiated syngeneic hosts. Experiments were performed with two syngeneic tumorβhost systems: the T5βBALB/c tumor line chronically infected with
Tumors, such as the murine Lewis lung carcinoma (LLC), produce granulocyte-macrophage colony-stimulating factor (GM-CSF), which increases the proportion of CD34 Ψ hematopoietic progenitor cells in the bone marrow and in the periphery. This increase in peripheral CD34 Ψ cells had been attributed to t