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The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo

✍ Scribed by Michael T Buckley; Joanne Yoon; Herman Yee; Luis Chiriboga; Leonard Liebes; Gulshan Ara; Xiaozhong Qian; Dean F Bajorin; Tung-Tien Sun; Xue-Ru Wu; Iman Osman


Book ID
119905467
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
991 KB
Volume
5
Category
Article
ISSN
1479-5876

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Activity of the histone deacetylase inhi
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## Abstract Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. __In vitro__ proliferation assays demonstrated that belinostat potently i