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Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates

✍ Scribed by Katherine E. Warren; Cindy McCully; Henrik Dvinge; Jette Tjørnelund; Maxwell Sehested; Henri S. Lichenstein; Frank M. Balis


Publisher
Springer
Year
2007
Tongue
English
Weight
237 KB
Volume
62
Category
Article
ISSN
0344-5704

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✍ Xiaozhong Qian; Gulshan Ara; Evan Mills; William J. LaRochelle; Henri S. Lichens 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 751 KB

## Abstract Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. __In vitro__ proliferation assays demonstrated that belinostat potently i