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The heregulin gene can be included in the 8p12 amplification unit in human breast cancer

✍ Scribed by José Adélaïe; Frédérique Penault-Llorca; Amel Dib; Yosef Yarden; Jocelyne Jacquemier; Daniel Birnbaum

Book ID
102846782
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
754 KB
Volume
11
Category
Article
ISSN
1045-2257

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✦ Synopsis

The Heregulin (HGL) gene, encoding a ligand for a member of the ERBB receptor family, is located at 8p12-p22, in or close to a region frequently amplified in breast carcinoma. Amplification of HGL was detected in three of 83 (3.6%) cases of breast tumors. No overexpression of the gene was observed in the amplified tumors. This and the low incidence of amplification suggest that HGL is not the key gene of the 8p I 2 amplification but may be used as a marker of large amplification units. Genes

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