The role of 12 cDNA-expressed human, rod
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Magang Shou; Kenneth R. Korzekwa; Charles L Crespi; Frank J. Gonzalez; Harry V.
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Article
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1994
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John Wiley and Sons
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English
β 881 KB
## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__β7, 8βdihydrodiol (7, 8βdiol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino