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Induction of the Cytochrome P-450c gene and the metabolism of benzo(a)pyrene-7,8-diol (BP7,8-diol) in eight different human breast cancer cell lines

✍ Scribed by Pasanen, M.; Lykkesfeldt, A.; Autrup, H.


Book ID
123160649
Publisher
Elsevier Science
Year
1987
Weight
118 KB
Volume
23
Category
Article
ISSN
0277-5379

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino