Transforming function of the LSM1 oncogene in human breast cancers with the 8p11–12 amplicon
✍ Scribed by Streicher, K L; Yang, Z Q; Draghici, S; Ethier, S P
- Book ID
- 110072008
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 590 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Amplification of 8p11‐12 has been recurrently reported in sporadic breast cancer. These studies define a complex molecular structure with a set of minimal amplified regions, and different putative oncogenes that show a strong correlation between amplification and over‐expression such as
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## Abstract Recently, we analysed the 8p11‐12 genomic region for copy number and gene expression changes in a panel of human breast cancer cell lines and primary specimens. We found that __SFRP1__ (Secreted frizzled related protein 1) is frequently under expressed even in breast tumours with copy n