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A 1 Mb minimal amplicon at 8p11–12 in breast cancer identifies new candidate oncogenes

✍ Scribed by Garcia, Maria J; Pole, Jessica C M; Chin, Suet-Feung; Teschendorff, Andrew; Naderi, Ali; Ozdag, Hilal; Vias, Maria; Kranjac, Tanja; Subkhankulova, Tatiana; Paish, Claire


Book ID
110069787
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
508 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract The chromosomal region 11q13 is amplified in 15–20% of breast cancers; an event not only associated with estrogen receptor (ER) expression but also implicated in resistance to endocrine therapy. Coamplifications of the 11q13 and 8p12 regions are common, suggesting synergy between the am