The growing applications of click chemistry

✍ Scribed by Moses, John E.; Moorhouse, Adam D.

• Book ID: 111939202
• Publisher: Royal Society of Chemistry
• Year: 2007
• Tongue: English
• Weight: 633 KB
• Volume: 36
• Category: Article
• ISSN: 0306-0012
• DOI: 10.1039/b613014n

✦ Synopsis

Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.