Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology
β Scribed by Zhang, Xiu; Zhang, Yan
- Book ID
- 121444237
- Publisher
- Molecular Diversity Preservation International
- Year
- 2013
- Tongue
- English
- Weight
- 679 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1420-3049
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## Abstract In recent years, there has been an everβincreasing need for rapid reactions that meet the three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions would allow medicinal chemistry to keep pace with the multitude of information derived from moder
We synthesized [ 11 C]methyl azide ([ 11 C]MeA) by reacting [ 11 C]methyl iodide ([ 11 C]MeI) in situ with an azide-donor and used it in the synthesis of 11 C-labeled 1,2,3-triazoles. A one-pot click approach comprised the infusion of gaseous [ 11 C]MeI into a mixture of NaN 3 , ethynylbenzene, and