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The genetics of human systemic lupus erythematosus

✍ Scribed by Betty P. Tsao

Book ID
116577499
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
372 KB
Volume
24
Category
Article
ISSN
1471-4906

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Major advances in understanding the genetic foundation of systemic lupus erythematosus are in the offing. Genetic association studies suggest multiple effects that include those encoded by the HLA region, the genes for Fcgamma receptors and other genes such as that for the mannose-binding protein. G

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Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease with partially understood etiology, which can affect virtually any organ. Despite suggestions to the contrary, SLE is proving to be a reliable phenotype for genetic studies. Similar to many other autoimmune diseases, SL