Major advances in understanding the genetic foundation of systemic lupus erythematosus are in the offing. Genetic association studies suggest multiple effects that include those encoded by the HLA region, the genes for Fcgamma receptors and other genes such as that for the mannose-binding protein. G
Unraveling the genetics of systemic lupus erythematosus
β Scribed by Harley, John B. ;Kelly, Jennifer A. ;Kaufman, Kenneth M.
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 257 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0344-4325
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Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in th