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Genetics of human systemic lupus erythematosus: the emerging picture

✍ Scribed by Swapan K Nath; Jeff Kilpatrick; John B Harley

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
129 KB
Volume
16
Category
Article
ISSN
0952-7915

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✦ Synopsis

Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease with partially understood etiology, which can affect virtually any organ. Despite suggestions to the contrary, SLE is proving to be a reliable phenotype for genetic studies. Similar to many other autoimmune diseases, SLE demonstrates a complex pattern of inheritance that is consistent with the involvement of multiple susceptibility genes as well as environmental risk factors. During the past several years, some new candidate genes have been implicated in induction of SLE through association studies, and multiple susceptibility regions have been detected through genome-wide linkage studies. Many of the susceptibility effects have been confirmed by independent studies.

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