✦ LIBER ✦

The emerging role of interferon in human systemic lupus erythematosus

✍ Scribed by Emily C Baechler; Peter K Gregersen; Timothy W Behrens

Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 320 KB
Volume: 16
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2004.09.014

No coin nor oath required. For personal study only.

✦ Synopsis

Recent studies of patients with systemic lupus erythematosus, together with data from lupus-prone mice, suggest that inappropriate activation of type I interferon might have a role in disease pathogenesis. Serum levels of IFN-a are elevated in SLE patients, and gene expression profiling of peripheral blood cells shows that most lupus cases demonstrate an upregulation of IFN-responsive genes. Of interest, the I FN gene 'signature' correlates with more severe disease. The available data support a model whereby chromatin-containing immune complexes circulating in the blood of lupus patients stimulate leukocytes to produce IFN, which perpetuates disease. These emerging insights into the connection between IFN and lupus provide a host of new diagnostic and therapeutic opportunities.

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