Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(
✦ LIBER ✦
The “generic” effect of food on tacrolimus pharmacokinetics
✍ Scribed by R. W. Steiner; A. A. Feist
- Book ID
- 111754848
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 86 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0902-0063
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Administration of terfenadine (Seldane@) immediately after a high fat breakfast slightly affects the rate but not the extent of absorption relative to fasting administration. Mean peak levels of the active metabolite were increased by 13 per cent but delayed by 0.9 h while AUC was virtually the same