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The gene encoding the Ia-Associated invariant chain is located on chromosome 18 in the mouse

✍ Scribed by Kazuhiko Yamamoto; Georgia Floyd-Smith; Uta Francke; Norbert Koch; Wolfgang Lauer; Bernhard Dobberstein; Reinhold Schäfer; Günter J. Hämmerling

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
699 KB
Volume
21
Category
Article
ISSN
0093-7711

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✦ Synopsis

The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse x Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse Ii cDNA as a hybridization probe, we localized the gene coding for the invariant chain to mouse chromosome 18.

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