✦ LIBER ✦

The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter

✍ Scribed by Illana Gozes; Rina Avidor; Yaakov Yahav; Daniel Katznelson; Carlo M. Croce; Kay Huebner

Publisher: Springer
Year: 1987
Tongue: English
Weight: 582 KB
Volume: 75
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00273836

No coin nor oath required. For personal study only.

✦ Synopsis

Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21----6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.

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