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Ia associated Iichain is not encoded by chromosome 17 of the mouse

✍ Scribed by Norbert Koch; Günter J. Hämmerling; Jacek Szymura; Matthias R. Wabl


Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
351 KB
Volume
16
Category
Article
ISSN
0093-7711

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✦ Synopsis


Note added in proof

While this manuscript was in preparation we have learned that P. Jones has detected an allelic form of the [ i chain in a particular species of mus. Using this polymorphism and backcross studies Jones and coworkers found also that I i is not encoded by chromosome 17 (P. Jones, personal communication).


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The gene encoding the Ia-Associated inva
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The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse x Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse Ii cDNA as a hy