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The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

✍ Scribed by Pobezinskaya, Yelena L; Kim, You-Sun; Choksi, Swati; Morgan, Michael J; Li, Tao; Liu, Chengyu; Liu, Zhenggang


Book ID
109920707
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
549 KB
Volume
9
Category
Article
ISSN
1529-2908

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## Abstract Activation of innate immunity via toll‐like receptors (TLRs) is associated with neurodegenerative diseases, and some effectors, like tumor necrosis factor alpha (TNFΞ±) and interleukin 6 (IL‐6), directly contribute to neurodegeneration. We tested the hypothesis that prostaglandin (PG) E~