The structure and absolute configuration of natural 8-epi-9-deoxygoniopypyrone have been confirmed by an efficient and highly diastereoselective synthesis in 15 steps from (S)mandelic acid with an overall yield of 43%.
The first total synthesis of 15-epi-annonin I
✍ Scribed by Ingo Wöhrle; Arno Claßen; Marcus Peterek; Hans-Dieter Scharf
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 226 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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The first total synthesis of epi-cochlioquinone A has been achieved in a highly convergent manner via [3+3] cycloaddition of catechol 2 and oxadecalin 3 as the key reaction. The synthesis of the catechol segment, possessing the side chain with multi stereogenic centers, features the asymmetric vinyl