The first synthesis of the epoxide-conta
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Joanne E. Harvey; Steven A. Raw; Richard J.K. Taylor
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Article
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2003
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Elsevier Science
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French
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A synthesis of the epoxydiene-containing macrolide nucleus of oximidine I is reported, starting from commercially available 3-butyn-1-ol. The key macrocyclisation step is achieved using Horner-Wadsworth-Emmons methodology in the presence of an epoxide.