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Studies toward the Synthesis of Oximidines I and II

โœ Scribed by Haack, Torsten; Kurtkaya, Serdar; Snyder, James P.; Georg, Gunda I.


Book ID
127358654
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
93 KB
Volume
5
Category
Article
ISSN
1523-7060

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A synthesis of the epoxydiene-containing macrolide nucleus of oximidine I is reported, starting from commercially available 3-butyn-1-ol. The key macrocyclisation step is achieved using Horner-Wadsworth-Emmons methodology in the presence of an epoxide.