An improved procedure for the preparation of a versatile synthetic precursor, (+)-~, of carba-2'-deoxyribonucleosides and the first stereospecific way to enantiomerically pure carbocyclic 2 '-deoxyadenosine , (+)-li, are presented from bicyclic lactone diol (+)-1. An unexpected formation of the disu
✦ LIBER ✦
The first stereospecific synthesis of (+)-(1r,2s,4r)-4-amino-2-hydroxy-1-cyclopentanemethanol and (+)-carbocyclic thymidine.
✍ Scribed by L. Ötvös; J. Béres; Gy. Sági; I. Tömösközi; L. Gruber
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 231 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Starting from 2,3‐__O__‐(3‐pentylidene)‐D‐glyceraldehyde (3), we prepared the bicyclic pheromone (1__S__,2__S__,4__R__,5__R__)‐(−)‐β‐multistriatin (1) on a gram scale. Key steps of the synthesis are a __cis__‐selective Wittig olefination followed by diastereo‐selective Michael addition