The First Example of a Diastereoselective Thio-Ugi Reaction: A New Synthetic Approach to Chiral Imidazole Derivatives
β Scribed by Gulevich, Anton V.; Balenkova, Elizabeth S.; Nenajdenko, Valentine G.
- Book ID
- 115534694
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 169 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The first example of aza-Nenitzescu reaction is described. Tile interaction of azaenaminebenzaldghyde phenylhydrazone with p-benzoquinone and cltiorobenzoquinone leads to a new synthesis of 5-hydroxyindazoles and indazole quinones.
Alkyl and S-aryl thioesters react with nitriles in the presence of triflic anhydride to form substituted 4-alkylthio-and 4-arylthiopyrimidines. However, when methyl thiocyanate is used as nitrile, dithioimidocarbonates are formed. A mechanism to explain these differences is postulated.