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The Reaction of Thioesters with Nitriles. A New Synthetic Approach to the Preparation of Substituted 4-Alkylthio- and 4-Arylthiopyrimidine Derivatives.

✍ Scribed by Antonio Herrera; Roberto Martinez-Alvarez; Pedro Ramiro


Publisher
John Wiley and Sons
Year
2003
Weight
127 KB
Volume
34
Category
Article
ISSN
0931-7597

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The reaction of thioesters with nitriles
✍ Antonio Herrera; Roberto Martı́nez-Alvarez; Pedro Ramiro πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 138 KB

Alkyl and S-aryl thioesters react with nitriles in the presence of triflic anhydride to form substituted 4-alkylthio-and 4-arylthiopyrimidines. However, when methyl thiocyanate is used as nitrile, dithioimidocarbonates are formed. A mechanism to explain these differences is postulated.