The first enantioselective synthesis of the amino acid, (2S,3S,4R)-?-hydroxyisoleucine using a palladium(ii) catalysed 3,3-sigmatropic rearrangement
β Scribed by Jamieson, Andrew G.; Sutherland, Andrew; Willis, Christine L.
- Book ID
- 117990023
- Publisher
- Royal Society of Chemistry
- Year
- 2004
- Tongue
- English
- Weight
- 100 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/b401076k
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π SIMILAR VOLUMES
The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (a-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate.
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