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The first design and synthesis of [11C]MKC-1 ([11C]Ro 31-7453), a new potential PET cancer imaging agent

✍ Scribed by Min Wang; Mingzhang Gao; Kathy D. Miller; George W. Sledge; Gary D. Hutchins; Qi-Huang Zheng


Book ID
116799620
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
999 KB
Volume
37
Category
Article
ISSN
0969-8051

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synthase kinase-3 (GSK-3) Radiosynthesis Positron emission tomography (PET) Cancer Alzheimer's disease a b s t r a c t SB-216763 is a novel, potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor with an IC 50 value of 34 nM. , a new potential PET agent for imaging of GSK-3, was first de