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Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents

โœ Scribed by Qi-Huang Zheng; Xiangshu Fei; Xuan Liu; Ji-Quan Wang; Hui Bin Sun; Bruce H Mock; K Lee Stone; Tanya D Martinez; Kathy D Miller; George W Sledge; Gary D Hutchins


Book ID
117687872
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
244 KB
Volume
29
Category
Article
ISSN
0969-8051

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Synthesis of MMP inhibitor radiotracer [
โœ Xiangshu Fei; Qi-Huang Zheng; Xuan Liu; Ji-Quan Wang; K. Lee Stone; Kathy D. Mil ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 95 KB

## Abstract [^11^C]CGS 25966, a novel radiolabeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agent. The precursor was labeled by [^11^C]methyl triflate through Oโ€[^11^C]methylation method at the hy