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Synthesis and preliminary biological evaluation of radiolabeled O6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in breast cancer

✍ Scribed by Qi-Huang Zheng; Xuan Liu; Xiangshu Fei; Ji-Quan Wang; David W. Ohannesian; Leonard C. Erickson; K. Lee Stone; Gary D. Hutchins


Book ID
117687928
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
180 KB
Volume
30
Category
Article
ISSN
0969-8051

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Synthesis of radiolabeled O6-benzylguani
✍ Qi-Huang Zheng; Xuan Liu; Xiangshu Fei; Ji-Quan Wang; David W. Ohannesian; Leona 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 121 KB

## Abstract Novel radiolabeled O^6^‐benzylguanine derivatives, 2‐amino‐6‐O‐[^11^C]‐[(methoxymethyl)benzyloxy]‐9‐benzyl purines ([^11^C]__p__‐O^6^‐AMBP, **1a**; [^11^C]__m__‐O^6^‐AMBP, **1b**; [^11^C]__o__‐O^6^‐AMBP, **1c**), have been synthesized for evaluation as new potential positron emission to