Synthesis of MMP inhibitor radiotracer [11C]CGS 25966, a new potential pet tumor imaging agent

✍ Scribed by Xiangshu Fei; Qi-Huang Zheng; Xuan Liu; Ji-Quan Wang; K. Lee Stone; Kathy D. Miller; George W. Sledge; Gary D. Hutchins

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: French
• Weight: 95 KB
• Volume: 46
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.675

✦ Synopsis

Abstract

[^11^C]CGS 25966, a novel radiolabeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agent. The precursor was labeled by [^11^C]methyl triflate through O‐[^11^C]methylation method at the hydroxyl position of phenol under basic conditions and isolated by HPLC purification to produce pure target compound in 15–25% radiochemical yield, based on ^11^CO~2~, decay corrected to end of bombardment. Copyright © 2003 John Wiley & Sons, Ltd.