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The expressions and significance of α-, β-catenins and cyclin D1 in breast cancers

✍ Scribed by Liang Zeng; Senlin Chen; Zhihong Liu; Jianfeng Yang


Publisher
Springer
Year
2008
Tongue
English
Weight
801 KB
Volume
7
Category
Article
ISSN
1610-1979

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␤-Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays also a role in intracellular signaling and can function as an oncogene when it binds to the T-cell factor 4 (Tcf4)-binding site in the promoter region of cyclin D1 and transactivates genes after translocation to the n