The Estimation of Some Analgetic Potencies
β Scribed by Tye, Arthur ;Christensen, B.V.
- Publisher
- Elsevier
- Year
- 1952
- Weight
- 282 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0095-9553
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π SIMILAR VOLUMES
titrant added. Reactions that go to cornpletion and give off or absorb heat adequately can be followed without the need for specific Calif. meeting, August 1959.
For inference regarding relative potency in dilution assays with possible latent effects, a robust procedure is proposed. Monte Carlo studies show that this procedure compares favourably with h o r n procedures. The theory is illustrated by an application to the tolerances of c a b for tinctures of
## Abstract Regression coefficients are regarded as stochastic variables in order to account for this kind of variability. This is needed, because differences in responses at successive doses vary generally and thus the assumption of constancy of regression coefficients is violated.
The paper considers the estimation of the potency of an unknown test preparation in relation to a standard in a dilution assay. The method utilizes the Mantel-Haenszel one degree of freedom chi-square approach to test consistency of the observed potency ratio with a range of alternative potency rati